Location, location, location! Intrabodies can probe protein interactions at specific intracellular sites

URL
https://www.aps.anl.gov/APS-Science-Highlight/2025-08-26/location-location-location-intrabodies-can-probe-protein
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One of the challenges of drug development is the management of side effects. With this goal in mind, researchers have been working on tools that will enable them to learn how to target drugs to specific intracellular locations and complexes. X-ray crystal structure data was used to help develop some of these tools.

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A series of labeled protein structures (visualized as colored ribbons) showing results of X-ray probes of synthetic antibody fragments.
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