19-ID, the In-Situ Nanoprobe (ISN), is a hard X-ray nanoprobe beamline operating in the energy range of 4.8 - 30 keV. The ISN instrument resides in the Long-Beamline Building (LBB) at a distance of 220 meters from the X-ray source. The beamline optics are optimized for high spatial resolution, long working distance and coherence preservation. Supported 2D and 3D imaging techniques include multimodal XRF microscopy, XRD microscopy, X-ray ptychography, and spectroscopic microscopy of X-ray induced electrical and optical signals. Combined with sample environments (electric fields, temperature) and in-situ capabilities (liquid or gas flow), the ISN provides a suite of tools for exploring dynamics of material structures during processes that occur either naturally or under external stimuli.