Experimental Physics and
Industrial Control System

I haven't tried using Pyepics with IronPython myself, but I believe that IronPython does support the ctypes module for foreign function interfaces, so it might just work without any changes.   I would not be surprised by one or two gotchas, but I would also expect those to be solvable. 

I should say that getting pyepics to work with 64-bit Python 2.7 on 64-bit Windows was problematic until some fix in ctypes with Python 2.7.9 (~18 months ago), and still requires a special-case in the code, as a call signature for callback functions is slightly different for 64-bit Windows from every other system.   See https://github.com/pyepics/pyepics/issues/31 for some notes on this.  I don't know if IronPython would have similar issues, but I could believe it might.

Anyway, I would suggest trying it.