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Users Week 2009
May 4-6, 2009

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Workshop 5:
Imaging Structural Hierarchy in Biological Systems

Organizers: Barry Lai (APS), Lee Makowski (Argonne National Laboratory), Gayle Woloschak (Northwestern University)

Date: Wednesday, May 6, 2009

Room: Bldg. 401, Rm. A1100

X-ray imaging of biomolecular systems is undergoing a revolution that will transform our understanding of biological systems at multiple length scales. X-rays have the unique capability of probing biological structures from centimeters to nanometers, often with thick samples and even in three dimensions. This workshop is designed to bring together researchers in the use of X-ray imaging to discuss the methods development and facilities upgrades that will be needed to apply the full range of imaging modalities to biological systems. The purposes of this workshop are (1) to highlight multi-length scale studies made possible by X-ray techniques, (2) bring together researchers to build the life science case for the APS Renewal, and (3) to explore synergy with other imaging modalities.

9:00 – 9:05 Welcome
9:05 – 9:35 X-ray Imaging Overview
Janos Kirz, Advanced Light Source
9:35 – 10:05 Biomedical Applications of Cellular and Structural Imaging
Lee Makowski, Argonne National Laboratory
10:05 – 10:35 Visualizing and Quantifying Fluid Flow and Respiratory Structures in Insects
Jon Harrison, Arizona State University
10:35 – 11:00 Coffee Break
11:00 – 11:30 X-ray Imaging of Bones, Teeth, and Regenerates
Thomas Diekwisch, University of Illinois at Chicago
11:30 – 12:00 Approaches to Molecular Imaging with X-ray Scatter-based Micro-CT
Erik Ritman, Mayo Clinic
12:00 – 1:30 Lunch
1:30 – 2:00 Multi-modality Image Analysis in Breast Cancer
Maryellen Giger, The University of Chicago
2:00 – 2:30 From the Cell to the Globe: What Synchrotron-based X-ray Microanalysis of Marine Bacteria and Protists can Tell Us about Biogeochemical Cycles
Stephen Baines, Stony Brook University
2:30 – 3:00 Inorganic Physiology: Subcellular Elemental Distributions in Normal and Pathological States
Tom O’Halloran, Northwestern University
3:00 – 3:20 Coffee Break
3:20 – 3:50 Probing Alterations in Bone Structure and Composition in Osteoporosis using Synchrotron-based Imaging
Lisa Miller, Brookhaven National Laboratory
3:50 – 4:20 Coherent Diffraction Imaging of Biomaterials
Ian McNulty, Argonne National Laboratory
4:20 – 5:00 Discussion and Wrap-up


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