Argonne National Laboratory

Users Week 2008
May 4-8, 2008

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Workshop 11

Synchrotron Radiation in Pharmaceutical Science: Freeze Drying and Other Applications

Thu. May 8, afternoon

Organizers: Dushyant B. Varshney (sanofi-aventis), Evgenyi Y. Shalaev (Pfizer, Inc.), Raj G. Suryanarayanan (University of Minnesota), Satyendra Kumar (Kent State University), and Larry A. Gatlin (Pfizer, Inc.)

To agenda > Updated 4/1/2008

Synchrotron radiation has been extensively utilized to characterize pharmaceutical materials. Conventional X-ray diffraction (XRD) methods have suffered from poor sensitivity and time resolution, mainly attributed to the low flux of the X-ray source. These limitations could be overcome with the use of highly collimated and intense synchrotron radiation, coupled with high resolution detectors. Synchrotron methods can provide superior signal-to-noise ratio, detection of processes in real time and in most cases quantitative information. The use of synchrotron radiation has led to developments in traditional areas such as phase quantification, strain measurements, and single crystal structure solution. It has also allowed investigations of dynamic & time resolved phase changes, solid state reactions, solving & refining crystal structures from powder XRD data, and analysis of the local structure of disordered and partially ordered solids such as amorphous materials and crystal mesophases. Recently, synchrotron methods have demonstrated a unique capability to monitor phase transitions during pharmaceutical processes such as freeze drying of complex multi-component systems. This workshop will focus on working and utility of synchrotron radiation to solve issues related to pharmaceutical science & research development.


1:00 - 1:10 Welcome & Overview
Dushyant B. Varshney, sanofi-aventis
  Session 1 Moderator: Dr. Douglas Robinson, Ames Laboratory
1:10 - 1:25 Place of SXRD in Pharmaceutical Development
Larry A. Gatlin, Pfizer Inc.
1:25 - 1:40 Freeze-drying of Pharmaceuticals - Use of Synchrotron Radiation
Raj G. Suryanarayanan (Sury), University of Minnesota and Dr. Dushyant B. Varshney, sanofi-aventis
1:40 - 2:15

The Applications of Synchrotron Radiations in Drug Development Setting - Case Studies
Shin Grace Chou and Evgenyi Y. Shalaev, Pfizer Inc.

2:15 - 2:35 Break
  Session 2 Moderator: Evgenyi Y. Shalaev, Pfizer Inc.
2:35 - 3:15

X-ray Powder Diffraction and Pairwise Distribution Function (PDF) Analysis of Disorder in Molecular Organic Solid Forms
Simon Bates, Aptuit Consulting

3:15 - 3:55

Fast Dynamics as an Indicator of Protein Stability in Glass
Marcus T. Cicerone, NIST

3:55 - 4:05 Break
4:05 - 4:55 X-ray Scattering Studies of the Early Stage of Phase Ordering Processes
Theyencheri Narayanan, ESRF
4:55 - 5:00 Closing Remarks
Dushyant B. Varshney, sanofi-aventis



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