Amphiphilic Four-Helix Bundle
Peptides Designed for Light-Induced Electron Transfer Across a Soft Interface
Shixin Ye, Bohdana M. Discher, Joseph Strzalka,
Ting Xu, Sophia P. Wu, Dror Noy, Ivan Kuzmenko, Thomas Gog, Michael J.
Therien, P.Leslie Dutton, J. Kent Blasie
5 (9), 1658-1667 (Sep. 2005)
A family of four-helix bundle peptides were designed to be amphiphilic, possessing
distinct hydrophilic and hydrophobic domains along the length of the bundle's
exterior. This facilitates their vectorial insertion across a soft interface
between polar and nonpolar media. Their design also now provides for selective
incorporation of electron donor and acceptor cofactors within each domain.
This allows translation of the designed intramolecular electron transfer
along the bundle axis into a macroscopic charge separation across the interface.