Protein Structure May Lead to Treatment for Infection Targeting Cystic Fibrosis Patients

Researchers using the Structural Biology Center 19-ID beamline at the APS have determined the structure of a key protein believed to play a role in a deadly infection that afflicts the lungs of patients with cystic fibrosis. This finding may lead to a new drug to treat the bacterial infection.

Read the text of the entire Argonne National Laboratory press release at: http://www.lightsources.org/cms/?pid=1001403

Contact: John_Mekalanos@hms.harvard.edu; andrzejj@anl.gov

See: J.D. Mouguos et al., "A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus," Science 312(5779), 1526 (2006). doi: 10.1126/science. 1128393

This work was supported in part by grants from the NIH and the U.S. Department of Energy, Office of Biological and Environmental Research, under contract W-31-109-Eng-38, and by the Damon Runyon Cancer Research Foundation.Use of the Advanced Photon Source was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. W-31-109-ENG-38

Argonne National Laboratory is a U.S. Department of Energy laboratory managed by The University of Chicago

 

 

 

Photo: Hcp1 crystal structure.