September 21, 2010
On average, one hundred billion cells in the human body divide over the course of a day. Most of the time the body gets it right but sometimes, problems in cell replication can lead to abnormalities in chromosomes resulting in many types of disorders, from cancer to Down Syndrome. Researchers utilizing two U.S. Department of Energy x-ray light sources have defined the structure of a key molecule that plays a central role in how DNA is duplicated and then used to produce two exact copies of the mother cell. Without this molecule, entire chromosomes could be lost during cell division, so this work is a major advance in understanding the molecules driving human genetic inheritance.