Tuesday, August 4, 1998
Wednesday, August 5, 1998
Thursday, August 6, 1998
Friday, August 7, 1998
Saturday, August 8, 1998

Tuesday, August 4, 1998

Session I (Morning):

Macromolecular Crystallography

Idea: Crystallographic experiments at synchrotron sources have evolved from near-heroic to near-routine, and certain classes of experiments such as MAD (multiple wavelength anomalous dispersion) and time-resolved are developing very briskly. How can experiments be further improved? What are the frontiers?

Session Chair:

Wayne Hendrickson (USA)


Roger Fourme (France)
Keith Wilson (UK)
Barry Stoddard (USA)
Ilme Schlichting (Germany)
Janet Smith (USA)

Session II-A (Early Afternoon):

Optics and Special Techniques

Idea: How does the interplay between apparatus and techniques on the one hand and scientific problems on the other work out in practice? Speakers will consider beamline components, detectors and other experimental components, as well as data analysis algorithms and software. See also Session V.

Session Chair:

Glaucius Oliva (Brazil)


Christian Riekel (France)
Michael Wulff (France)
Vukica Srajer (USA)
Wenbing Yun (USA)
Edgar Weckert (Germany) (invited)

Session II-B (Late Afternoon):


Idea: During this time, participants can take advantage of either self-guided or conducted tours of the Advanced Photon Source facility and beamlines of biologically oriented Collaborative Access Teams (CATs).

Session III (Evening):

Hot Topics

Idea: This session will include eight to 10 15-minute presentations selected at the last minute by a blue-ribbon panel from abstracts submitted in advance for the poster session. Only abstracts submitted by graduate-student or postdoctoral appointees will be considered.

Panel and Session Chair:

Hans Deisenhofer (USA) (invited)


To be selected

Wednesday, August 5, 1998

Session IV (Morning):

The Impact of Synchrotron Radiation on Biology and Biophysics: Past, Present, and Future

Idea: The first applications of hard x-rays emitted by synchrotron sources were to problems in biology (not materials science, physics or chemistry), in 1970-71 at Hamburg. What motivated those scientists? How would they perceive those earliest efforts now? In the following decades, the disciplines and phrases "biotechnology" and "structural biology" were coined, and these disciplines now have a strong synchrotron component. From an industrial perspective, what is and will be the impact of synchrotron radiation on biotechnology?

Novel uses of synchrotron radiation in biophysics are contemplated or underway, for example in experiments that exploit the coherence properties of the source, seek to generate and use ultra-short x-ray pulses, or subject the sample to unusual conditions. Fourth-generation x-ray sources that are based on linear accelerators rather than on circular rings are being considered. As we look into the crystal ball, what might we expect the next five to 10 years to hold?


Gerd Rosenbaum (USA)


Ken Holmes (Germany)
Keith Hodgson (USA)
Dale Sayers (USA)

Impact on Biotechnology

Tony Kossiakoff (USA)


Keith Watenpaugh (USA)


Paul Sigler (USA)


John Helliwell (UK)
Jim Penner-Hahn (USA)
Jochen Schneider (Germany)

Session V-A (Early Afternoon):

Apparatus and Techniques

Session Chair:

Eric Eikenberry (USA) (invited)


Elspeth Garman (UK)
Ke Zhang (USA)
Dean Chapman (USA)
Nguyen-huu Xuong (USA)

Session V-B (Late Afternoon):

First Poster Session

Poster Co-Organizer:

Andy Howard (USA)

Session VI (Evening):

"Meet the Experts"

Idea: Several small groups of senior scientists, each expert on a particular style of experiment (e.g., virus crystallography, time-resolved solution scattering, soft x-ray microscopy), apparatus (e.g., CCD detectors, ultra-small angle scattering cameras), systems (e.g., ribosomes and their subunits, muscle proteins, light-sensitive systems) or sources, will be available to meet casually with students and others who would like to chat about their own experiments or any topic related to synchrotron-based research. Each panel may contain two or three experts; there may be eight to 10 such panels, depending on participant interest and panelist willingness. The emphasis is on informality and topicality. How can we recruit new people to our favorite experiment, gadget, or source? How can we best educate our newcomers? See also Session IX.

Thursday, August 6, 1998

Session VII (Morning):

Scattering from Non-Crystalline Systems

Idea: Scattering from solutions, surfaces, fibers, and membranes is complementary to single-crystal studies and, of course, many systems cannot be crystallized. What is the present status of both static and time-resolved scattering experiments?

Session Chair:

Hugh Huxley (USA)


Jill Trewhella (USA)
Kent Blasie (USA)
Keiichi Namba (Japan)
Kate Poole (Germany)
Katsuzo Wakabayashi (Japan)
Martin Caffrey (USA)

Session VIII (Afternoon):

Microscopies and Medical Research

Idea: Synchrotrons are used for imaging of biological systems over a wide range of length scales: hundreds of nanometers (e.g., microscopy of subcellular organelles) to tens of centimeters (e.g., imaging of human organs). What, in the broadest sense, are the successes of and limitations on imaging? How can the limitations be overcome?

Microscopies Chair:

Günther Schmahl (Germany)


Chris Jacobsen (USA)
Gerd Schneider (Germany)
Cathy Magowan (USA)

Medical Research Chair:

Bill Thomlinson (USA)


Rainer Dix (Germany)
Tohoru Takeda (Japan)|
Per Spanne (France)

Session IX (Evening):

Meet the Experts

Idea: See Session VI.

Friday, August 7, 1998

Session X (Morning):

X-ray, VUV, and IR Spectroscopies

Idea: A wide range of spectroscopies (static, spatially resolved, and time-resolved) are pursued through use of synchrotron radiation. Taking advantage of proximity to the International EXAFS Conference, speakers will review the present state-of-the-art.

Session Co-Chairs:

Barry Dobson (UK) (invited)
John Sutherland (USA)


Steve Cramer (USA)
Hiro Oyanagi (Japan)
Lisa Miller (USA)
Jim Penner-Hahn (USA)
Samar Hasnain (UK)

Session XI-A (Early Afternoon):

Macromolecular Complexes: the Frontier with Cell Biology

Idea: Synchrotron sources enable the structures of very large macromolecular complexes (e.g., viruses, ribosomes, muscle proteins, DNA-protein complexes, multienzyme complexes, light-harvesting systems) to be probed by a variety of techniques. Such studies generally exploit the properties of synchrotron facilities to the fullest extent, and attack important biological questions more at the level of cell biology than of biophysical chemistry. How can the synchrotron/biology interface be enhanced? See also Session XII.

Session Chair:

Louise Johnson (UK)


Peter Colman (Australia)
Eva Pebay-Peyroula (France)
Ada Yonath (Israel)
Tomitake Tsukihara (Japan)

Session XI-B (Late Afternoon):

Second Poster Session

Poster Co-Organizer:

Grant Bunker (USA)

Saturday, August 8, 1998

Session XII (Morning):

Macromolecular Complexes: the Frontier with Cell Biology

Idea: See Session XI.

Session Chair:

Michael Rossmann (USA)


John Kuriyan (USA)
Paul Sigler (USA)
John Walker (UK)
M. Martin-Fernandez (UK)
John Johnson (USA)
David Stuart (UK)